Liquid Chromatography Time-Of-Flight Mass Spectrometry

Illuminates emerging analytical techniques in high resolution mass spectrometry including time-of-flight mass spec. Provides a database of accurate masses for organic molecules, making o.m. detection much easier. The most advanced techniques for analyzing unknown and emerging contaminants n recent years, we have witnessed an increase in mass accuracy from greater than 5 ppm to less than 1 ppm. At the same time, resolving power for benchtop time-of-flight mass instruments has increased from 2,000–5,000 to 10,000–20,000. Responding to these and other important new developments in mass spectrometry, this contributed work reviews, synthesizes, and analyzes the latest discoveries, techniques, and practical applications in accurate mass analysis. The authors are all leading experts, many of whom are pioneers in the development of time-of-flight techniques to address environmental problems. Liquid Chromatography Time-of-Flight Mass Spectrometry is divided into three parts: Part One: Principles and Theoretical Aspects of Accurate Mass, sets forth the fundamentals of accurate mass by liquid chromatography/time-of-flight (LC/TOF) mass spectrometry Part Two: Tools for Unknown Identification Using Accurate Mass, explores the gamut of TOF tools, including exact-mass databases, isotopic mass defects, and isotopic ratios and neutral losses Part Three: Applications of LC/TOF-MS for the Identification of Small Molecules, examines applications across a broad range of disciplines, including pharmaceuticals, pesticides, veterinary medicine, toxicology, forensics, environmental science, and food analysis Throughout the book, theoretical discussions are illustrated with concrete examples that show readers how to perform their own accurate analyses. By arming chemists with the principles,…