Protein Serine/Threonine Kinases in Neurodegenerative Disorders

Protein Serine/Threonine Kinases in Neurodegenerative Disorders provides a comprehensive overview of protein serine/threonine kinases (STKs) in health and disease. It also discusses protein kinase inhibitors and their potential role in modulating and treating neurodegenerative diseases. The book begins with an introduction to protein kinases and inhibitors, followed by detailed discussions on different types of kinases, including protein kinase C (PKC), AMP-activated protein kinase (AMPK), Death-associated protein kinase 1 (DAPK1), cyclin-dependent kinases (CDKs), glycogen synthase kinases (GSKs), Rho-associated protein kinase (ROCK), microtubule affinity regulating kinases (MARK), mammalian target of Rapamycin (mTOR), Leucine-rich repeat kinase 2 (LRRK2), PTEN-induced kinase 1 (PINK1), dual-specificity tyrosine phosphorylation-regulated kinase (DYRKs), and their roles in neurodegenerative disease, potential inhibitors, and therapeutic mechanisms. Protein Serine/Threonine Kinases in Neurodegenerative Disorders features 23 chapters written by renowned experts in kinases field. It explores novel targets modulated by protein kinases, including non-coding RNAs (ncRNAs), mitogen-activated protein kinases (MAPKs) activated by tyrosine receptor kinases, and their roles in neurodegeneration. It also discusses the nexus between glycogen synthase kinases (GSKs) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) and their metabolic regulation role in neurodegeneration. The modulatory effects of protein kinase B (PKB/AKT) pathways in various neurodegenerative disorders, particularly Parkinson’s disease, are also examined. The book sheds light on bioactive compounds from natural products that target kinases. The book explains the role of different kinases in various pathogenic…